Singapore and Global Integrated Delivery
Singapore Overview
Jacobs’ commitment to Singapore began in 1974. Today, we maintain 400 professionals based in our Singapore office. Our Jacobs Life Sciences (BioPharma) business delivers a wide range of complex projects efficiently and cost-effectively, supported by decades of local and regional expertise.
Our experience in Singapore Life Sciences (BioPharma) industry dates back to 2000. To date, Jacobs has designed and delivered around 90% of the BioPharma facilities in Tuas, Singapore.
Leveraging our comprehensive understanding of Singapore’s regulatory environment, community conditions, client expectations, and business culture, we provide end‑to‑end engineering, procurement, construction management, and validation (EPCmV) services. These span project inception and conceptual design through detailed engineering, construction management, supply chain management, commissioning, qualification and validation (CQV), and permitting.
Our Singapore‑based team is fully integrated with Jacobs’ regional and global network, enabling seamless access to specialist technical expertise and subject matter experts (SMEs) worldwide to meet project‑specific requirements.
Jacobs has been recognized by The Straits Times as one of Singapore’s Best Employers in 2022, 2023, and 2026, reflecting our continued commitment to excellence, people development, and workplace culture.
Global Integrated Delivery
We are the Global Integrated Delivery leader with an execution approach focused on lead office accountability, global resource expertise, standardized work practices, and a common virtual work space to ensure seamless collaboration and coordination. This allows us to provide local delivery with the ability to leverage global expertise.
With our vast network of global offices, we are well-positioned to deliver projects anywhere in the world, utilizing global Subject Matter Experts, project delivery centers of excellence, and local resources.
The benefits of using Global Integrated Delivery are clear - it gives access to a wider resource pool and allows Jacobs to provide clients with the optimal solutions.
Full Service Capability
Jacobs Pharma-Bio / Life Sciences Projects in Singapore
New API Manufacturing Facility
Location: Tuas, Singapore
Services: Site Masterplanning and Concept Design
Duration: 2026
The new API facility will be designed to comply with current Good Manufacturing Practices (cGMP) and applicable regulatory requirements, while supporting flexible production capabilities.
New Chemical Manufacturing Facility
Location: Tuas, Singapore
Services: Site Masterplanning and Concept Design
Duration: 2026
The new chemical facility will be designed to comply with ISO 9001 and applicable regulatory requirements, while supporting flexible production capabilities.
Greenfield Central Utility Building (CUB) Project
Location: Tuas, Singapore
Services: Basis of Development Design
Duration: 2026
The project involves the development of a greenfield Central Utility Building (CUB) in Tuas, Singapore. The facility will deliver centralized production and distribution of key utilities, including chilled water, steam, compressed air, and hot and cold glycol. It will be designed around an integrated thermal energy approach, leveraging heat recovery from key processes to meet heating requirements and enhance overall operational efficiency.
Biologics Manufacturing Plant Expansion
Location: Tuas, Singapore
Services: Basic Design & Detailed Design
Duration: 2023-2026
Jacobs is providing engineering services to expand biologics manufacturing capacity through the addition of a complete new production train. The new train, comprising four bioreactors, will operate concurrently with the existing production train to support increased capacity and operational flexibility.
The project includes product / cell freezer area, inoculum suites, cell culture suites, harvest and recovery suites, media prep; buffer prep / hold, purification suites, utility block and other site infrastructure.
Vaccine Facility
Location: Singapore
Services: Detailed Design, Procurement Support, field engineering support
(Warehouse, Utility & Site Infrastructure)
Duration: 2021-2025
The production center will supply vaccines mainly to Asia and complement the firm's existing manufacturing capacities in Europe and North America. The factory is in Tuas Biomedical Park and can produce three or four different types of vaccines simultaneously, as compared with current industrial sites which usually allow for the production of only one vaccine at any one time. This is because the new facility will tap digital technologies and single-use systems (SUSs) in vaccine manufacturing.
Singapore Biologics Project Design Package 1
Location: Tuas, Singapore
Services: Basic design, detailed design, and design services during construction for
project phase 1 consists of central warehouse, hazardous storage, waste storage,
central utility building, WWTP, spine corridor and piping rack.
Duration: 2023-2026
The project is a greenfield Biopharmaceutical Manufacturing campus in Tuas Singapore with an area of approximately 3.5 ha. The facilities will be used to manufacture biologics including drug substances and drug products of clinical phase and commercial production phase.
Hepatitis B Vaccine (HPV) Facility
Location: Tuas, Singapore
Services: Detailed Design
Duration: 2023-2026
Jacobs is providing AE services for the transfer of Hepatitis B bulk manufacturing to Tuas, Singapore. The project expands an existing brownfield facility and is being designed in parallel with ongoing Hepatitis B Vaccine (HBV) process improvement and modernization initiatives.
Pfizer API Manufacturing Facility
Client: Tuas, Singapore
Services: Site Master planning Permitting Support, Basis of Design and Detailed Design of Package A which includes the wet and dry buildings and tank farm
Duration: 2019-2025
This is a greenfield project for a new multi-product API Manufacturing Facility in Singapore including a 5-storey wet production building, milling building, and supporting infrastructure.
Dry Powder Inhaler Facility
Location: Tuas, Singapore
Services: Concept, Basic and Detail Design
Duration: 2020-2023
The client intends to set a Dry Powder Inhaler manufacturing facility in Singapore for clinical and commercial production in a brownfield facility. The new facility shall include manufacturing (blending, agglomeration, mixing, curing, filling, and packaging), incoming and outgoing product and material areas, support areas, including utilities.
Tuas Cell and Gene Facility
Location: Tuas, Singapore
Services: Feasibility, Site Master Planning & Concept Design
Duration: 2022-2023
The project is to expand the manufacturing capacity in Singapore by building a cell and gene therapy CDMO facility with approximately 7,500 M2 of cleanrooms and 1,000 M2 of R&D laboratories. The new facility shall include clean room (complete fit out), QC lab, warehouse and PD lab areas.
Tuas New API Manufacturing Facility
Location: Tuas, Singapore
Services: Site Master Planning & Concept Design
Duration: 2022-2023
Jacobs provided master plan and concept design services for a greenfield API manufacturing facility in Tuas, Singapore. The facility will replicate an API Manufacturing site located in China to a greenfield location in Tuas, Singapore.
- Overall Site Master Planning to comply local Singapore codes.
- Treating facility discharges to meet Singapore environmental regulations.
- Initial concept design for Tuas infrastructure and utility integration.
- Designing building services utilities to account for the different climatic conditions in Tuas versus China
Clinical GMP Facility
Location: Singapore
Services: Concept Design
Duration: 2021 – 2022
Jacobs provided concept design services for the brownfield clinical manufacturing facility project which can support multi products, multi-modalities of vaccines and biologics manufacturing. The project includes two drug substances (DS) suites – microbial cell-based production train and mammalian cell-based platform productions, and one pilot scale drug product (DP) formulation and fill, bench scale lyophilization suites.
Nutarian Project
Client: DuPont / Danisco
Location: Tuas, Singapore
Services: Concept Design, Basic Design, EPCM
Duration: 2018-2020
The Project is a pilot blending plant consists of a liquid and a dry blending suite with supporting facilities like office, sample room, loading, unloading and receiving, utilities areas, retrofitted into a 2-storey industrial building.
Mechanical completion was achieved on 15 Dec 2020.
API Thermal Oxidiser
Location: Tuas, Singapore
Services: EPCm
Duration: 2020 – 2023
The Thermal Oxidizer (TOx) project involved retrofit modifications to an existing API brownfield facility, including the installation of a dedicated wastewater treatment (WWTP) unit and integration with existing process systems. The project was implemented to remediate vent emission sources and ensure compliance with corporate standards and Singapore National Environment Agency (NEA) requirements, positioning the facility for future regulatory readiness.
TOx system has been fully commissioned and handover to operations successfully in Feb 2023. Plant startup and running in March 2023.
Utility Combination Project
Location: Tuas, Singapore
Duration: 2023-2024
Role: Feasibility Study
The project intends to evaluate the utilization of utility services for both B1 and B10 and combine those possible services for Buildings B1 and B10.
The combined utilities will optimize the usage of equipment which in turn improves the efficiency of the equipment. It will also provide additional redundancy which can be utilized for future expansions.
By combining the utility services of both buildings, Roche will also be compliant with the K18 directive (Energy conservation) which is an integral part of Roche’s commitment to sustainable development.
Compounding Line 3 Project
Location: Tuas, Singapore
Services: Basic Design, Detail Design, Procurement and Construction Management
(PCM)
Duration: 2023-2026
The Client intends to do fit out of new compounding suite 3 in existing shell space to increase the general eye care product manufacturing capacity. The project includes cleanroom construction, new air handling units, and installation of clean and black utilities and power/instrumentation cabling.
Our Global Life Sciences Subject Matter Experts
Chris Davis
Bulk Biologics / Process SME
Chris is a chartered chemical engineer and Fellow of the Institution of Chemical Engineers. He has over 25 years of experience in the biopharmaceutical industry and has established himself as an innovative and widely respected expert in the fields of process design, technical leadership, production, process scale-up, biocontainment, safety and associated regulatory issues.
Chris’ strong technical skills have been proven time and again and are reflected in his published work, his work in higher education and his industrial presentations, remaining ahead of the curve and abreast of the most up to date technical advances. Whilst his experience was built on bacterial, yeast and cell culture systems he also provides support to the emerging medicinal fields of gene, cell and immuno-therapies.
His recent projects provide evidence of his proven technical excellence. Chris’ flexibility and experience have also seen him define and guide the design of new facilities and new suites in existing facilities, leveraging both stainless steel and single use technologies to provide cost-effective facilities and operational excellence for clients. Chris has developed a unique skillset, working on projects ranging in value from €20 m to €700 m, taking his experience in option evaluation, unit operation design and different process systems to deliver highly efficient designs for clients across Ireland and Europe, mixing process experience, technical knowledge and project management to achieve reliable results.
Charles Smith
Process SME
Charles has over 25 years of process and mechanical engineering experience in the design of biopharmaceutical facilities including engineering, procurement, construction assistance, start-up and validation of biotech operations including single use technologies.
These systems include USP and WFI purified water, support utilities and cell culture/purification manufacturing processes including media/buffer prep, bioreactors, harvest, chromatography and ultrafiltration / diafiltration.
Curt Biehn
Process Architect
Curt is an Architectural SME and Facility Design Manager with over 30 years of Jacobs experience in Life Sciences. Throughout this time, he has worked on Cell and Gene Therapy, Drug Substance, Drug Product, Vaccine Manufacturing and other Pharmaceutical related facilities.
Curt has been responsible for the architectural design of multiple Life Sciences research, development and manufacturing facilities and campuses. His responsibilities have included site evaluation and master planning; benchmarking facilities to establish parameters and objectives; project scope development; programming and conceptual design; cGMP gap analysis and remediation; presentations and documentation for local, state, and FDA project approval.
Julie Vickers
Process SME
Julie is a highly motivated process engineer with 28 years in the biotechnology, pharmaceutical, and semiconductor industries. She can work independently or lead a team to meet critical deadlines. Her primary subject matter expertise includes cell and gene therapy, viral vectors, mRNA, LNP, cell culture and downstream purification systems. Julie current is a sole patent holder for a single use heat exchanger and is an expert at employing single use technology.
Peter Cramer
Process SME
Peter has 28 years of experience on a broad range of advanced technology projects including biotechnology, pharmaceutical, and micro-electronic projects. He has expertise in designing biotechnology and pharmaceutical cGMP manufacturing facilities. He’s a proven leader of programming, conceptual design, and detailed design production teams on complex, state-of-the-art designs. Peter also has exceptional architectural design capabilities combined with a documented track record of “on-time” and “on-budget” project delivery.
Don Fraser
Automation / Digital 4.0 SME
Don has over 30 years of experience in manufacturing operations and automation for pharmaceuticals, consumer goods, and paper mills for grass roots and modernization projects. His project roles include system testing, factory test lead, start-up and commissioning lead, team leads, project engineer, controls engineer, project lead, and project manager. His areas of expertise include Pharmaceutical/Biotechnology automation systems, Manufacturing Execution Systems, Single Use Technology in Biologics, Product & Equipment Tracking (Track & Trace), Systems design using S95 & S88, and Batch and continuous process automation.
Francesca McBride Regulatory, CQV SME
Francesca has over 30 years of experience in the Pharmabio and Medical Device industries. She has provided Regulatory Compliance and Validation expertise to clients seeking facility and product licensing or accreditation by regulatory agencies, including the FDA, USDA, and the NIH/CDC in the United States; and the EMEA, ANVISA, MHLW, TGA, NMPA, CDSCO, WHO, PICS internationally. As an integral part of the Jacobs EPCMV teams, Francesca has provided cGMP compliance direction to Jacobs’ clients and the project teams in the clarification and understanding in the application of international GMP requirements supporting facility design and the project planning/scheduling of the integration of construction, ASTM E2500 for commissioning and validation activities to support the project schedule and obtain regulatory approval.
From August 1993 to January, 1995, Ms. McBride was assigned to the Jacobs Engineering European Region as Manager, Regulatory Compliance. She was responsible for the start-up of the Regulatory Compliance and
Validation departments in this region. From August 2001 to August, 2003, Ms. McBride was assigned to the Wyeth BioPharma Project in Ireland as Validation Program Manager as part of Wyeth’s Integrated Commissioning and Validation (ICV) team. From October 2009 to April 2010, Ms. McBride was assigned as a senior regulatory and validation specialist in India to support the start-up of a vaccine manufacturing facility
Maria Elena Gasperini
Sustainability SME
Maria Elena has 20 years of experience in Sustainability and Consultancy. Her experience covers a wide variety of markets including pharmaceutical, built environment, mission critical and advanced facilities. She is supporting projects and organizations on sustainability aspects, developing strategies and targets, working on carbon neutrality, energy efficiency, waste minimization, water reduction and sustainable resources.
With reference to international certifications like LEED, WELL, BREEAM, her experience covers pre-assessment, definition of sustainable strategy, coordination of design teams and contractors, LEED and WELL Administration. Maria Elena has successfully developed with her team LEED, BREEAM, DGNB and WELL certifications for major projects in both the pharmaceutical and building sectors.
She is active member of the board of the Green Building Council Italia, promoting design according to LEED and WELL and other green-building protocols (e.g., BREEAM and DGNB). She is also part of the Italian board of the #BuildingLife Initiative, promoted by the World Green-Building Council.
Currently, Maria Elena is the Director of Sustainability Life Sciences Europe. She works with important clients as Pfizer, Horizon, Amazon, Novo Nordisk, Ferring, Shell, Chiesi, Intesa Sanpaolo, BNL, DeA Capital, Sonae Sierra, Eli Lilly, Johnson & Johnson, Bracco, Novartis, Yara, Dow, Huntsman.
Maria Elena has also a strong background in Quality Management Systems and Performance Improvement Projects; she has managed successfully international certification schemes (e.g., ISO 9001 Quality Management Systems, as well as ISO 14001, OHSAS 18001) both for companies and for projects.
Paddy Cummins CQV SME
Paddy is a chartered mechanical engineer with over 25 years of extensive experience in the fields of mechanical and HVAC engineering design, commissioning and building services project management. Paddy has extensive experience in the micro-electronics, healthcare, pharmaceutical and commercial industries. He is currently the manager for the Commissioning, Qualification and Validation department in Ireland. Previously he was the HVAC and Mechanical Department Manager and previous to that led mechanical engineering teams on variety of projects for many global pharmaceuticals companies.
Projects worked on a variety of green and brown field sites ranging in size from €50k to €800 million in value.
Mary Lennon
CQV & Compliance SME
Dr. Mary Lennon has over 30 years of experience in the pharmaceutical and food industries. She has been with Jacobs for 26 years and is one of our leading experts in the field of Commissioning, Qualification Validation (CQV) and GMP Regulatory Compliance. She has provided Regulatory Compliance and CQV expertise to clients seeking facility and product licensing or accreditation by regulatory agencies such as FDA, EMEA, NMPA specifically.
Her blend of technical excellence and management experience has made her perfect for managing large, cross-functional teams of both scientists and engineers. Clients such as GSK, Pfizer, Novartis, Novo Nordisk, BioMarin have benefited from Mary’s expertise across the full lifecycle of API, Biopharma Drug Substance and Fill Finish and Quality Support activities.
Mary is a leading figure in Jacobs with her development of training courses and best practices ensuring she has remained at the cutting edge of the industry.
Todd Rumsey
Process SME
Todd has over 25 years of multi-discipline design experience in the biotech and pharmaceutical industries. His design experience spans the process, process simulation, automation, and validation disciplines. Todd has 14 years of Jacobs experience working extensively on bulk biologics, ATMP, and RNA/DNA facilities. His skill set includes the design and operation of process equipment such as bioreactors, centrifuges, dead-end and tangential flow filtration, chromatography, clean-in-place, and single-use systems. He has expertise in the optimization of process system and utilities through computer simulation, capacity planning, and the design of intelligent software tools. His experience spans multiple continents including North and South American, Europe and Asia.
Alex Brindle
Process SME
Alex has been in the life science industry for 24 years and during that time responsible for over 30 Feasibility and Conceptual Design projects. Mr. Brindle’s experience covers consulting to project implementation for Drug Development, Manufacturing Operations, Process Design & Optimization, Business Case Development and Quality Initiatives to improve process and product quality.
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