Oral Solid Dosage (OSD)

At Jacobs, we are your partner in innovation. Our global network of subject matter experts remain at the forefront of the industry to provide you with cutting edge solutions that reflect today’s technology, regulatory, and business needs. Oral Solid Dosage (OSD) technology is constantly evolving due to new technological development, targeted delivery requirements, business pressures, regulatory changes, and increasing active pharmaceutical ingredient (API) potency. In many cases the delivery system and biological target of the API is as important as the API itself.

Equipment technology is still developing to meet the unique and opposing challenges posed by aseptic and high containment processing. Products have unique characteristics, clients have specific needs, and regulators sometimes have unique expectations. There is not a one design fits all solution for high potent aseptic Fill Finish Facilities. We have worked with clients and Filling Line, Isolator and Lyophilizer equipment vendors to remain at the forefront of this technology journey. Our accomplished project base covers almost every product category, dosage form, unit operation, and facility type. Clients benefit from decades of Jacobs experience in direct, dry, and wet granulation; specialty granulation; dosage technology; milling technologies, tablet coating, packaging, and containment equipment design. Our tableting plant for Wyeth Pharmaceuticals was the first secondary manufacturing facility built in Singapore and was immediately followed by our tableting projects for Schering Plough and GlaxoSmithKline.

Pfizer | DP Zith Powder | Kalamazoo, MI

Eli Lilly | Dry Kit 3 | Carolina, Puerto Rico

Types of Manufacturing and Support Areas Designed:

  • Granulation - High Shear / Single Pot Fluid Bed
  • Drying / Fluid Bed / Conveyor / Vacuum
  • Blending / Milling
  • Tablet Compression
  • Encapsulation – Solid & Liquid
  • Tablet Coating – Solvent & Aqueous
  • Continuous Processing
  • Tablet & Capsule Packaging
  • Isolator – Contained Processing
  • Modular Facilities

Manufacturing Technology includes:

  • Multi-purpose
  • High Containment
  • Cryogenic / High Energy
  • Filter Dryer / Agitated Dryer
  • Waste Treatment Minimization
  • Milling / Blending
  • CIP
  • Modular
  • Membrane Separation

Jacobs leads the global professional services sector providing solutions for a more connected, sustainable world. jacobs.com